Luis Saldaña, MD, MBA, FACEP, CMIO, Maxine Ketcham, Clinical Decision Support Applications Analyst, Texas Health Resources, and Brita Hansen, MD, CMO, LogicStream Health. Texas Health Resources (THR) is achieving clinical improvement by hardwiring evidence-based practices into their clinical processes across all 14 of its hospitals using Clinical Process Improvement (CPI) methodologies. This talk discusses why CPI is foundational to THRs journey to high reliability, so that for every patient, every time, at every facility, care teams are consistently doing the right thing. The organizational framework and keys to success employed by THR are shared, including integration with Clinical Decision Support within the EHR and how this work is tracked to facilitate sustained performance improvement over time. Finally, they present a representative use case and share other examples of success.