Mimi Hassett, MS, RN, FHIMSS, Director of Clinical Informatics, Berkshire Health Systems, Pittsfield, MA, describes how nursing can optimally lead and support the successful integration of information systems, including development, implementation and enhancing the user experience. The issues, impacts and influences on the definition of such roles are discussed, as are tools such as job description analysis, employment and project evaluations, and professional standards as set by the American Nurses Association.