Siraj Anwar, MBBS, MS, CPHIMS, Associate CMIO, Memorial Hermann Health System. Memorial Hermann began their clinical decision support journey 12 years ago when they set out to implement Computerized Physician Order Entry across the entire health system. Over the years, with the help of the clinical decision support alerts, they have been able to positively impact the care that is provided to the patients. With much focus and attention on “Alert Fatigue,” it is important to understand the key principles and considerations when implementing Clinical Decision Support alerts in the EHR. What role do clinicians and informaticists play? How does data help drive the decision making process? And what are the data analytics tools that could help make the process of implementation and optimization more efficient? These are all questions that are addressed in this session.