John Pirolo, MD, EVP, CMIO, Saint Thomas Health, and Gail Zielinski, Director, BI/HIE, Ascension Information Services. This presentation describes a holistic approach to selection and validation of a system-wide clinical business intelligence platform. Dr. Pirolo and Gail also discuss early value opportunities, including the use of clinically driven analytics to influence behavioral change (and improve outcomes), and the delivery of analytics support to system-wide clinical quality initiatives. Many lessons learned and opportunities for improvement are also shared.