Peter J. Hotez, MD, PhD, Dean, School of Tropical Medicine, Baylor College of Medicine; Professor of Pediatrics and Molecular Virology & Microbiology, Baylor College of Medicine; Adjunct Professor, UT School of Public Health; Chair, Tropical Pediatrics, Texas Children’s Hospital; and Co-Director, Texas Children’s Center for Vaccine Development (CVD). COVID-19 vaccine development, manufacturing, and distribution is a complex and multi-layered process. From his perspective as a vaccine scientist and public health professional, Dr. Hotez provides an update on COVID-19 vaccine clinical trials in process, parallel global planning for manufacturing and distribution, and key insights learned to date from clinical research regarding the COVID-19 disease progression and impact.