Loran Hauck Senior, MD, VP, CMO, Office of Clinical Effectiveness, Adventist Health System, and David Classen, MD, CMIO and David Stockwell, MD, VP Clinical Services, Pascal Metrics. It is often claimed at a high level that Health IT has the potential to improve quality and reduce cost. But how? Adventist Health System has leveraged a triad of data from its EMR, an automated approach to finding all-cause harm in real-time, and focused improvement efforts based on this concurrent and predictive data. Using this it has implemented a program of harm management that is already showing that it can spot millions of dollars’ worth of preventable harm events across their initial hospitals. This operational approach, in the context of a Patient Safety Organization, is a powerful tool for moving toward high-reliability and reduced cost.