Tina Esposito, VP, Center for Health Information Services, Darcy Davis, Data Scientist, and Fran Wilk, Clinical Process Designer, Advocate Health Care. With annual cost estimates as large as $300 billion, non-adherence to medications is an enormous opportunity in the Accountable Care era. As a large ACO, Advocate Health Care is working to more effectively intervene in improving adherence. Leveraging both clinical and claims data, clinicians are now equipped with more meaningful patient-specific adherence information at the point of care. Further, data insights have yielded deeper understanding that supports refocused interventions to improve outcomes and cost.