Margaret Reynolds, RN, PhD, FAAN, Director of Evidence Based Practice, and Marti Satwicz, RN, MSN, Director of Clinical Transformation, CHE Trinity Health. In October 2010, Trinity Health launched a system-wide Sepsis Collaborative in 21 of its hospitals. Margaret and Marti describe the collaborative strategies used to disseminate evidence-based practices for sepsis and identify tools/decision support that fostered improved outcomes for sepsis patients. Data over a two-year period indicated a reduction in mortality from 15.8% (baseline) to 13% and a reduction of $20 million in direct variable costs. They also identify key challenges to the provision of evidence based sepsis care.