Jim Conway, Principal, Pascal Metrics and Adjunct Lecturer, Harvard School of Public Health, and David Classen, MD, MS, Associate Professor of Medicine at the University of Utah and CMIO, Pascal Metrics. In September 2012, the IOM Committee on the Learning Health Care System in America released the product of its deliberations with the report “Best Care at Lower Cost”. Identified are three major imperatives for change: the rising complexity of modern health care, unsustainable cost increases, and outcomes below the system’s potential. Emerging tools like computing power, connectivity, team-based care, and systems engineering techniques make the envisioned transition possible, and are already being put to successful use in pioneering healthcare organizations. A review of the findings and the journey forward will be presented by a member of this committee and a member of IOM Committees on Patient Safety and Health IT.